Montrael Scott scored 14 to lead the Panthers (2-10), who finished 1-8 on a nine-game road swing.
Playing for the first time in two weeks, the Badgers were a little rusty from 3-point range. Averaging 40 percent coming in, they finishing 9 for 27 from beyond the arc. However, everything else was working as they dominated at the free-throw line and in rebounding while committing just two turnovers.
Prairie View went to a zone defense early, which helped slow down the Badgers somewhat.
Wisconsin was 21 of 28 from the line, compared to 3 of 4 for the Panthers, and outrebounded Prairie View 42-25. The Badgers also turned 16 offensive rebounds into 19 points.
Though the Panthers weren't terribly sloppy with the ball, committing 13 turnovers, Wisconsin turned those mistakes into 17 points. Prairie View only had two points off the Badgers' two turnovers.
The Badgers opened the game by outscoring Prairie View 23-6 over the first 10 minutes of the game and were never challenged.
Wisconsin opens Big Ten play Thursday at Northwestern.
Prairie View A&M return home Jan. 4 to take on Southern in the Panthers' conference opener.