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PHILADELPHIA -- This was the Cam Newton who was the talk of the NFL last season.

Newton threw for two touchdowns and ran for two more to lead the Carolina Panthers to a 30-22 victory over the Philadelphia Eagles on Monday night in a matchup of teams with the worst records in the NFC.

Newton, who hadn't played up to his sensational rookie season, showed no signs of a sophomore slump against Philadelphia's porous pass defense. He finished 18-of-28 for 306 yards and had a passer rating of 125.

"I think my best game is still to come," Newton said. "I'm still focused on getting better each and every week."

Philadelphia's Bryce Brown set a club rookie record with 178 yards rushing, including TD runs of 65 and 5 yards, but the Eagles (3-8) still lost their seventh straight game.

Brown, filling in for injured running back LeSean McCoy, surpassed Correll Buckhalter's rookie mark of 134 yards rushing in his first start since his senior year at Wichita East High School in 2008. But Brown also lost two fumbles, including one in Panthers territory.

Fellow rookie Nick Foles was so-so in his second straight start for Michael Vick, who sat out with a concussion. Foles was 16-of-21 for 119 yards.

"The most important thing for me was for us to get the win, and that didn't happen tonight," Brown said. "I felt like a lot of that had to do with my two turnovers. It really, really cost us."

Carolina (3-8) went ahead 24-22 early in the fourth quarter on Graham Gano's 23-yard field goal.

Then the Panthers finally stopped Brown when it mattered most, stuffing him on a fourth-and-1 to take over on downs at their 40. Newton led them downfield, running in from the 2 to make it 30-22. Gano, signed last week, missed the extra point. But Brandon Boykin fumbled after a 44-yard kickoff return, and the Panthers recovered and held the ball the final 4:29.

"It's been a long time in coming," Panthers coach Ron Rivera said. "Lots of people contributed and made plays. Real proud of what we did and the things we did to give ourselves a chance to win."

Newton, the No. 1 overall pick in the 2011 NFL draft, lived up to the hype by throwing for 4,051 yards with 21 TD passes and 14 TDs on the ground in his first year. He entered this game with only nine TD passes and four TDs rushing, a major disappointment for Panthers fans.

But Newton outshined a rookie seventh-round pick in his Monday night debut.

"We took some plays off his plate and really tried to balance it out and spread it among other players, and he has really responded very well to those things," Rivera said. "I think we had to interpret it as giving him a breath once in a while. These last few weeks, he's played like the guy we believe he could become."

Newton had a 24-yard TD toss over the middle to a wide-open Gary Barnidge for a 7-3 lead. He connected with Brandon LaFell on a 43-yard pass to make it 14-3 later in the first quarter. LaFell was wide open on the play, taking advantage of another breakdown in coverage in the secondary.

Since Todd Bowles replaced Juan Castillo as defensive coordinator, the Eagles have allowed 13 passing touchdowns and haven't had an interception in five games.

Newton led a 95-yard drive to open the third quarter, finishing it off with a 1-yard leap to give the Panthers a 21-15 lead. Newton hit Louis Murphy for a 55-yard gain on a second-and-11 from Carolina's 16.

A 51-yard pass interference call on Haruki Nakamura on Foles' deep pass to Jeremy Maclin put Philadelphia at the Panthers' 5. Brown then ran in for the go-ahead score.

Brown broke loose early in the second quarter to get Philadelphia within 14-12. Brown started up the middle, cut outside and outran the defense down the right sideline for the seventh-longest TD run by a Philadelphia rookie. The Eagles inexplicably tried a 2-point conversion and failed.

"Bryce did what we thought he could do," Eagles coach Andy Reid said. "He's a talented kid. It's a shame he had the two fumbles. He was on a roll. Those things cost you. He'll learn from it. He's got a great future."

Alex Henery's 45-yard field goal gave them a 15-14 lead. Henery kicked a 41-yarder to cut it to 14-6 in the second quarter. It was his 18th straight field goal, setting a team record.

The Eagles haven't won since beating the defending Super Bowl champion New York Giants to go 3-1, leaving fans and media to speculate about Reid's job. Owner Jeffrey Lurie already has said that an 8-8 record would be "unacceptable" this year. The Eagles would have to finish 5-0 just to get there.

"I'm not worried about all the other things," Reid said. "We haven't talked about that. He's been supportive. Obviously he's competitive and wants to win games."

Fans known for their hostile behavior have become apathetic toward their beloved Eagles. The Linc was about one-third empty for pregame introductions, and plenty of seats remained empty at the start. There were boos early when the Eagles fell behind, but they lacked the usual luster.

The Panthers have shown they're better than their record. They have lost six games by less than a touchdown, including a 2-point loss at Atlanta and a 1-point loss at Chicago.

"It's a huge stage, 'Monday Night Football,' on the road," tackle Jordan Gross said. "It was just big for us and big for the guys on the team who haven't experienced something like this."

The injury-depleted Eagles lost wide receiver DeSean Jackson (sternum) and defensive tackle Fletcher Cox (tail bone) in the first half.

Game notes

Neither Vick nor McCoy has been cleared to return to practice. ... The Eagles inducted five-time Pro Bowl cornerback Troy Vincent and longtime front-office executive Leo Carlin into the team's Hall of Fame at halftime. ... Brown's 65-yard TD run was the longest for the Eagles since McCoy's 66-yarder against the New York Giants on Nov. 1, 2009. ... Buckhalter had 134 yards rushing versus Arizona on Oct. 7, 2001. ... Newton led the Panthers with 52 yards rushing.