Guillaume Desbiens opened the scoring for Colorado at 12:20 of the second period with a 45-foot wrist shot past Jonas Hiller's glove, following a turnover by forward Jakob Silfverberg in the Anaheim zone. Silfverberg left the game with 5:02 remaining because of an undisclosed injury.
Kyle Palmieri tied it 57 seconds into the third on a breakaway goal set up by defenseman Francois Beauchemin, who played his first game since reconstructive surgery on his right knee.
Hiller finished with 23 saves.
Varlamov had a league-worst 21 losses and a 3.02 goals-against average for Colorado during the lockout shortened 48-game schedule in 2012-13.
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ANAHEIM, CA - SEPTEMBER 22: Colin Smith #37 of the Colorado Avalanche dives for the puck in front of Jakob...